Peter A Noble
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Research Assistant Professor University of Washington Seattle, WA 98195-2700 ph 206-685-7583 fx 206-685-3836 panoble@u.washington.edu Personal Webpage |
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Peter Noble received his Bachelor of Science (Honors) in marine biology and Master of Science at Memorial University of Newfoundland. He received his Ph.D. in Applied Microbiology at University of Saskatchewan. He was a post-doctoral fellow at University of California, Irvine and Center of Marine Biotechnology at University of Maryland, Baltimore.
EDUCATION
Ph.D., University of Saskatchewan, 1994
M.Sc., Memorial University of Newfoundland, 1984
B.Sc.(Honors), Memorial University of Newfoundland, 1982
RESEARCH INTERESTS
Oligonucleotide DNA microarrays for microbial identification and quantification
Molecular to landscape modelling of estuarine eutrophication
Mathematical approaches for examining complexity and self-organizing properties of biological and ecological systems
PUBLICATIONS
Pozhitkov, A. and P. A. Noble. (2008) Unraveling microbial communities using oligonucleotide arrays: where microbiology meets physicochemistry. (in review)
Pozhitkov, A. E., P. A. Noble, G. Nies, B. Kleinhenz, D. Tautz, and M. Brouwer. (2008) Are ghost genes haunting your expression array study? (in review)
Pozhitkov, A., R. A. Rule, R.G. Stedtfeld, S.A. Hashsham and P. A. Noble*. (2008) Concentration-dependency of nonequilibrium thermal dissociation curves in complex target samples. Journal of Microbiological Methods. doi: 10.1016/j.mimet.2008.03.010.
Pozhitkov, A. E,G. Nies, B. Kleinhenz, D. Tautz, and P. A. Noble*. (2008) Simultaneous quantification of multiple nucleic acids in target mixtures using high density microarrays. Journal of Microbiological Methods (accepted: May 7, 2008).
Pozhitkov, A., D.Tautz, and P. A. Noble. (2007) Oligonucleotide arrays: widely applied -- poorly understood. Briefings in Functional Genomics and Proteomics doi:10.1093/bfgp/elm014. [PDF]
Pozhitkov, A., K. D. Bailey, and P. A. Noble. (2007) Development of a statistically robust quantification method for microorganisms in mixtures using oligonucleotide microarrays. J Microbiol. Methods 70:292–300. [PDF]
Pozhitkov, A., R.D. Stedtfeld, S.A. Hashsham, and P. A. Noble. (2007) Revision of the nonequilibrium thermal dissociation and stringent washing approaches for identification of mixed nucleic acid targets by microarrays. Nucleic Acids Research35: e70. [PDF]
Pozhitkov, A. and P.A. Noble. (2007) High variability in melting profiles from gel pad arrays. Environmental Microbiology. 9:1865 [PDF]
Pozhitkov, A., and P. A. Noble. (2007) Comment on discrimination of shifts in soil microbial communities using nonequilibrium thermal dissociation and gel pad array technology. Environmental Science and Technology 41, 1797-1798 [PDF] and Supplementary material [PDF] 10.1021/es062479m
Pozhitkov, A. E., P. A. Noble, T. Domazet-Loso, A. Nolte, P. Staehler, M. Beier, and D. Tautz. 2006. Tests of rRNA hybridization to microarrays suggest that hybridization characteristics of oligonucleotide probes for species discrimination cannot be predicted. Nucleic Acids Research 34:e66. [PDF] and Supplementary material [PDF]
Noble, P.A. and E. Tribou. (2006). Neuroet: an easy-to-use artificial neural network for ecological and biological modelling. Ecological Modelling. 203, 87-98 [PDF].
Pozhitkov, A., B. Chernov, G. Yershov, and P. A. Noble. 2005. Evaluation of gel-pad oligonucleotide microarray technology using artificial neural networks. Applied and Environmental Microbiology 71, 8663-8676. [PDF]
Morris, J., D. Porter, M. Neet, P. A. Noble, L. Schmidt, L. A. Lapine, and J. Jensen. (2005). Salt and brackish marsh characterization at North Inlet, SC using LIDAR-derived elevation data and land cover extracted from multispectral imagery using a neural network. International Journal of Remote Sensing 26, 5221-5234. [PDF]
Kelly, J. J., S. Siripong, J. McCormack, P. A. Noble, L. Sappelsa, H. Urakawa, S. El Fantroussi, B. E. Rittmann, and D. A. Stahl. (2005). DNA microarray detection of nitrifying bacterial 16S rRNA in wastewater treatment plant samples. Water Research 39, 3229-3238. [PDF]
Lewitus, A. J., D.L. White, R.G. Tymowski, M.E. Geesey, S.N. Hymel and P.A. Noble. (2005). Adapting the CHEMTAX method for assessing phytoplankton taxonomic composition in southeastern U.S. estuaries. Estuaries. 28, 160-172. [PDF]
El Fantroussi, S., H. Urakawa, A. E. Bernhard, J. J. Kelly, P. A. Noble, H. Smidt, G. M. Yershov, and D. A. Stahl. (2003). Direct profiling of environmental microbial populations by thermal dissociation analysis of native ribosomal rRNAs hybridized to oligonucleotide microarrays. Applied and Environmental Microbiology 69, 2377-2382. [PDF]
Noble, P. A., R. G. Tymowski, J. T. Morris, M. Fletcher, and A. J. Lewitus. (2003). Contrasting patterns of phytoplankton community pigment composition in two salt marsh estuaries in Southeastern United States. Applied and Environmental Microbiology 69, 4129-4143. [PDF]
Urakawa, H., P. A. Noble, S. El Fantroussi, J. J. Kelly and D. A. Stahl. (2002). Single-base pair discrimination of terminal mismatches by using oligonucleotide microarrays and neural network analyses. Applied and Environmental Microbiology 68, 235-244. [PDF]
Urakawa, H., P. A. Noble, S. El Fantroussi, J. J. Kelly and D. A. Stahl. (2002). Optimization of single-base-pair mismatch discrimination in oligonucleotide microarrays. Applied and Environmental Microbiology 69, 2848-2856. [PDF]
Ogunseitan, O.A., J. LeBlanc, and P. Noble. 2002. Ecological dimensions of microbial proteomics. Recent Research Developments in Microbiology 6, 487-501.
Almeida J. S., J. A. Carrico, A. Maretzek A, P. A. Noble, and M. Fletcher. (2001) Analysis of genomic sequences by chaos game representation. Bioinformatics 17, 429-437. [PDF]
Noble, P. A., J. S. Almeida, and C. R. Lovell. (2000) Application of neural computing methods for interpreting phospholipid fatty acid profiles from natural microbial communities. Applied and Environmental Microbiology 66, 694-699. [PDF]
Almeida, J. S. and P. A. Noble. (2000) Neural computing in microbiology. Journal of Microbiological Methods 43, 1-2. [PDF]
Noble, P. A. (1999) Minireview: a hypothetical model for monitoring microbial growth by using capacitance measurements. Journal of Microbiological Methods 37, 45-49. [PDF]
Noble, P. A., M. Dziuba, D. J. Harrison, and W. L. Albritton. (1999) Factors influencing capacitance-based monitoring of microbial growth. Journal of Microbiological Methods 37, 51-64. [PDF]
Piceno, Y. M., Noble, P. A., and C. R. Lovell. (1999) A comparison of diazotroph assemblages in two vegetated salt marsh zones using denaturing gradient gel electrophoresis (DGGE) analysis. Microbial Ecology 38, 157-167. [PDF]
Noble, P. A., R. W. Citek, and D. A. Ogunseitan (1998) Tetranucleotide frequencies in microbial genomes. Electrophoresis 19, 528-535. [PDF]
Noble, P. A., K. D. Bidle, and M. Fletcher (1997) Natural microbial community compositions compared by a back- propagating neural network and cluster analysis of 5S rRNA. Applied and Environmental Microbiology 63, 1762-1770. [PDF]
Noble, P. A., D. L. Clark, and B. H. Olson (1996) Biological stability of ground water treated for organic carbon removal by conventional and membrane filtration methods. Journal of the American Water Works Association 88, 87-96.
Dasgupta, M. K., K. Ward, P. A. Noble, M. Larabie, and J. W. Costerton (1994) Development of bacterial biofilms on silastic catheter materials in peritoneal dialysis fluids. American Journal of Kidney Diseases 23, 709-716.
Albritton, W. L., P. A. Noble, and K. D. Webster (1994) Clarification of the plasmid RSF0885 in Haemophilus influenzae serotype b. Canadian Journal of Microbiology 40, 154-157.
Dziuba, M., P. A. Noble, and W. L. Albritton (1993) A study of the nutritional requirements of a selected Haemophilus ducreyi strain by impedance and conventional methods. Current Microbiology 27, 109-113.
Noble, P. A., E. Ashton, C. A. Davidson, and W. L. Albritton (1991) Heterotrophic plate counts of surface water samples by using impedance methods, Applied and Environmental Microbiology 57, 3287-3291.
Noble, P. A., P. E. Dabinett, and J. A. Gow (1990) Numerical taxonomic study of pelagic and benthic surface-layer bacteria in seasonally-cold coastal waters. Systematic and Applied Microbiology 13, 77-85.
Journal Publications